인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Polyamine metabolism is a key regulator of cellular proliferation and immune modulation, and its dysregulation is implicated in multiple carcinoma pathogenesis. Macrophages also greatly influence tumor progression by regulating the immune microenvironment. However, the role of polyamine metabolism in thyroid cancer macrophages remains understudied. This study explores the connection between polyamine metabolism and macrophages in thyroid cancer. Using the THCA dataset gene expression analysis and single-cell data, we identified macrophage subpopulations. We assessed immune scores, matrix scores, immune checkpoint scores, and immune cell types using Bulk-RNA data and the TIDE platform to predict immune checkpoint inhibitor responses. Clinical specimens validated our findings. Our results show a significant association between polyamine metabolism and the clinical and biological characteristics of thyroid cancer, including macrophage trajectory. Notably, macrophage subpopulations affected by polyamine metabolism have strong prognostic value, especially in immunotherapy patients. We found that changes in these subpopulations correlate with thyroid cancer development, and tumor tissue can regulate macrophage polyamine metabolism. This study provides new insights into how polyamine metabolism affects macrophages and the tumor microenvironment, influencing tumor growth and anti-tumor immune responses in thyroid cancer.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
