인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Background Chronic obstructive pulmonary disease (COPD), a prevalent chronic respiratory disorder, has prompted growing interest in the neutrophil percentage to albumin ratio (NPAR) as a novel inflammatory biomarker. However, the precise relationship between COPD and NPAR dynamics remains elusive. Methods This study investigated the correlation between NPAR and COPD in adults using National Health and Nutrition Examination Survey (NHANES) data from 2015 to 2018. Logistic regression models and smoothed curve fitting showed a threshold effect and two-segment linear regression. Subgroup analyses were conducted to assess demographic differences, strengthening the study’s reliability. The research included 729 COPD patients and 530 controls, identifying factors affecting NPAR in COPD patients and confirming the NPAR-COPD link with Pearson correlation. Results This study found that COPD patients had significantly higher NPAR than healthy controls (HCs) ( p < 0.05), with older patients (≥ 60 years) showing higher NPAR than younger ones ( p = 0.051). After adjusting for covariates, a significant link between COPD and NPAR was observed (OR = 1.016, 95% CI: 1.003–1.029, p = 0.017). The risk association was nonlinear, with an inflection point at NPAR of 9.36. Linear regression analysis suggested that factors like hypertension, hemoglobin, WBC count, neutrophil count, lymphocyte percentage, ALT, and AST could influence the NPAR index in COPD patients (all p < 0.05). The ROC curve analysis showed an AUC of 0.648, which improved to 0.778 upon validation with a retrospective cohort model. Conclusion This study reveals a significant correlation between elevated NPAR and COPD, particularly in the presence of aged above 60 years.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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