인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Background Systemic lupus erythematosus (SLE) is a multisystemic disease, caused by a variety of factors. Osteopontin (OPN) is a pleiotropic protein, important in bone remodeling and immune system signaling. The variant rs1126616 of osteopontin (OPN) gene has been associated with over expression of OPN which plays important role in pathogenesis of immune-mediated diseases. Also, tumor necrosis factor like weak inducer of apoptosis (TWEAK), was found to be up-regulated in the blood and urine of individuals with lupus nephritis (LN), suggesting its potential as a biomarker for LN. This study aimed to detect the association of the (rs1126616) variant of the OPN gene, serum level of OPN and urinary level of TWEAK in SLE patients and LN among a group of Egyptian females. Methods Case control study which included 90 participants, 60 SLE patients were clinically confirmed, of which 30 were SLE without nephritis, 30 were SLE with nephritis, and 30 apparently healthy individuals as a control group. The rs1126616 variant of OPN gene was genotyped using Taqman Real-Time PCR, also level of serum osteopontin, and urinary TWEAK were measured by ELISA. Results OPN gene variant rs1126616 was observed to be statistically significant different between the SLE group and control group ( P value = 0.022). There was a statistically significant increase in serum OPN level in SLE cases compared to control group ( P < 0.001). Regarding u TWEAK /creatinine ratio, it was statistically higher in the LN cases compared to SLE without nephritis and the control group ( P value = 0.047, 0.001 respectively). Conclusion OPN rs1126616 and serum OPN level may play a role in pathogenesis of SLE. uTWEAK/creatinine ratio could be a good diagnostic marker for L.N.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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