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Elsevier BV Journal of Biological Chemistry 301(5)
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    초록·키워드

    Several viruses including HIV-1 and other retroviruses are known to spread directly between cells. Direct cell-to-cell spread allows viruses to evade the antibody-based immune defense and thus infection becomes significantly more efficient. Viruses have been observed to interact with cell junctions; however, detailed mechanisms of transfer have not been defined. Gap junctions (GJs), which provide direct cell-to-cell communication (GJIC) use channels assembled from connexin (Cx) proteins that cluster into large arrays in the adjacent membranes of neighboring cells.

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