인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
ABSTRACT Idiopathic pulmonary fibrosis (IPF) is an irreversible and fatal lung disease characterized by persistent alveolar epithelial cell injury and extracellular matrix deposition. Early dual modulation of oxidative stress and inflammation may offer a promising therapeutic opportunity. Mesenchymal stem cell‐derived extracellular vesicles (MSC‐EVs) offer therapeutic promise but face challenges in scalability and efficient lung delivery. Here, we developed a biomimetic extracellular vesicle‐spherical nucleic acid (BEV‐SNA) platform for IPF therapy. BEV‐SNA were constructed by integrating mechanically extruded BEVs from primary MSCs with cholesterol‐modified ssDNA through hydrophobic co‐assembly. In stemness‐maintained P0‐P1 MSCs, the production of BEVs increased by 17.2‐fold compared to natural EVs. Benefiting from a three‐dimensionally dense and negatively charged DNA shell, BEV‐SNA reduce airway adhesion, enabling deep pulmonary delivery and efficient cellular uptake. In IPF models, BEV‐SNA demonstrated multiphase therapeutic effects, including protection of alveolar epithelial cells from ROS, anti‐inflammatory activity, and late‐stage anti‐fibrotic action, effectively halting fibrosis progression and achieving a 50% survival rate in mice. This study presents a novel therapeutic platform combining the natural biomimicry of EVs with the functional adaptability of SNAs, proposing an innovative strategy for pulmonary drug delivery and the treatment of respiratory diseases.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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