인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Porcine epidemic diarrhea (PED) is a highly contagious intestinal disease owing to porcine epidemic diarrhea virus (PEDV) infection. It is extremely detrimental to newborn piglets and has caused huge economic losses to the global pig industry. In this study, three PEDV strains of G2a PEDV-WF/2023, G2b PEDV-SX/2024 and PEDV-HS/2024 were successfully isolated from small intestine tissue samples with the analysis of their molecular structure characteristics, genetic characteristics and pathogenicity. Notably, these three PEDV strains had multiple unique aa mutations and extensive N-glycosylation in the D0 region, S1-NTD, COE epitope and SS6, respectively. Therefore, their structures were different compared to CV777 and PT-P5 strains. Furthermore, all the three PEDV strains caused severe clinical symptoms in 1-day-old piglets after infection. Among them, G2a PEDV-WF/2023 was the most detrimental to piglets, with highly levels of viral RNA in vivo. In contrast, PEDV-HS/2024 showed relatively weak pathogenicity to piglets, but it also caused the death of piglets. It might be attributed to the occurrence of individual mutations consistent with the amino acid sequence of G1b subtype in PEDV-HS/2024 strain. Findings in this study allow us to confirm that the G2a PEDV-WF/2023 strain is currently one of the most harmful epidemic strains to piglets. This study may benefit our understanding of the molecular structure characteristics, evolution trend and transmission dynamics of the epidemic strains in China. Moreover, it may provide potential reference for formulating more targeted PEDV vaccines, preventing and controlling this infection, and further curbing the cross-species spread of PEDV.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
