인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
The development of bladder cancer is a complex, multistep process influenced by both genetic and environmental factors, but its exact etiology remains unclear. Increasing evidence suggests that gut microbiota dysregulation can impact the initiation and progression of cancers, including colorectal cancer, breast cancer, and pancreatic cancer. This study observes that the beneficial gut bacterium Parabacteroides distasonis (P. distasonis) is significantly decreased in bladder cancer patients, and its low abundance is strongly associated with poor prognosis. P. distasonis is a next-generation probiotic which plays a vital role in human health. Furthermore, this work finds that P. distasonis culture medium inhibits metastasis and proliferation of bladder cancer cells in vitro and in vivo. This work identifies that indole-3-acetic acid (3-IAA) produced by P. distasonis exerting similar tumor-suppressive effects. Mechanistically, 3-IAA activates the aryl hydrocarbon receptor (AhR), which in turn downregulates fatty acid synthase (FASN) transcription in bladder cancer cells. Notably, the reduction of FASN expression decreases the ratio of MUFAs to PUFAs, thereby increasing ferroptosis sensitivity in bladder cancer cells. Collectively, this study demonstrates that P. distasonis-derived 3-IAA can inhibit bladder cancer metastasis and proliferation, highlighting the AhR-FASN axis as a promising therapeutic target to inhibit bladder cancer progression.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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