인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Candidemia is a life-threatening bloodstream infection associated with high mortality rates, particularly in critically ill patients. Accurate risk stratification is crucial for timely intervention and could improve patient outcomes. This study aimed to enhance the predictive performance of the sequential organ failure assessment (SOFA) score by developing a modified SOFA (mSOFA) score, which is specifically designed for candidemia patients. Using data from MIMIC-III, MIMIC-IV, and ICU-JN databases, we identified key prognostic variables through LASSO regression and integrated into the mSOFA_3 model. The model incorporated respiratory_SOFA, coagulation_SOFA, and circulatory_SOFA along with clinical biomarkers, including lactate, albumin, and blood urea nitrogen. The mSOFA_3 model demonstrated superior predictive performance across multiple machine learning algorithms, with the logistic regression-based model achieving the highest AUC of 0.826 in the internal validation cohort and 0.813 in the test cohort. Kaplan-Meier survival analysis further validated the model's utility in stratifying patients into high-risk and low-risk groups with distinct survival outcomes. These findings highlight the mSOFA_3 as a robust and clinically relevant tool for early risk stratification, offering potential for improved decision-making and therapeutic management in critically ill patients with candidemia.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.