인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
The increasing demand for sustainable machining necessitates the development and toxicological evaluation of environmentally friendly alternatives to conventional metalworking fluids (MWFs). This study investigated the respiratory and systemic effects of a nanoparticle-enhanced vegetable oil-based MWF (NPVO-MWF) using a whole-body inhalation exposure model in male C57BL/6 mice. Both sub-acute (4-week) and sub-chronic (13-week) exposures were performed, followed by detailed bioanalytical and histopathological assessments. Cytokine analyses (IL-1β, TNF-α, IL-6) via ELISA and RT-PCR revealed no significant pro-inflammatory responses. Reactive oxygen species (ROS) levels in blood, bronchoalveolar lavage fluid, and lung homogenates remained unchanged, indicating an absence of oxidative stress. Histopathological analysis using hematoxylin and eosin staining showed mild epithelial hyperplasia in sub-chronic exposures. Sirius Red staining revealed minimal collagen deposition and slight reductions in pulmonary airspace. No substantial evidence of lung injury, pulmonary toxicity, or carcinogenicity was observed. This study represents one of the first applications of a whole-body inhalation model for evaluating NPVO-MWFs, addressing a critical gap in occupational health risk assessment. The findings indicate that NPVO-MWFs present low toxicological risk under the tested conditions and offer a viable, sustainable alternative to conventional MWFs. Additional chronic exposure studies are recommended to further establish their occupational safety.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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