인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Early life air pollution exposure may play a role in development of respiratory infections, but underlying mechanisms are still not understood. We utilized data from two independent prospective birth cohorts to investigate the influence of prenatal and postnatal ambient air pollution exposure of PM<sub>2.5</sub>, PM<sub>10</sub> and NO<sub>2</sub> on maternal and child proteomic profiles and the risk of daily diary-registered common infections age 0-3 years in the Danish COPSAC<sub>2010</sub> (n = 613) and pneumonia, croup and bronchitis age 1-2 years in the Swedish EMIL (n = 101). A supervised sparse partial least square model generated proteomic fingerprints of air pollution analyzed against infection outcomes using Quasi-Poisson and logistic regression models, respectively. Here we demonstrated that prenatal ambient air pollution exposure was associated with altered maternal proteomic profile with significant downregulation of the AXIN1 protein. The prenatal air pollution proteomic fingerprints related to a significantly higher risk of total number of infections, cold, pneumonia and fever episodes in COPSAC<sub>2010</sub> and similar postnatal air pollution proteomic fingerprints related to a significantly higher risk of respiratory infections in EMIL. Higher AXIN1 protein levels associated with significantly decreased risks of total number of infections, cold, pneumonia, tonsillitis and fever episodes, and asthma risk in COPSAC<sub>2010</sub> and a significantly decreased risk of respiratory infections in EMIL suggesting a protective effect of this specific protein in both cohorts. This study of two prospective birth cohorts demonstrates ambient air pollution alterations in the maternal and child's proteomic profiles that associates with respiratory infection risk suggesting the AXIN1 protein as a potential target for respiratory infection and asthma prevention in childhood.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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