인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Purpose Cerebral palsy (CP) frequently results in developmental delays and long-term physical impairment. This study aims to evaluate serum biochemical and extracellular biomarkers, specifically matrix metalloproteinases (MMP-2 and MMP-9), in children with CP as an initial step to investigate their potential involvement in the condition’s etiopathogenesis. Methods Forty children diagnosed with CP and 20 healthy age-matched study participants were included. Demographic and clinical data were collected using a structured proforma. Serum samples were analyzed for biochemical parameters (ALT, AST, ALP, total protein, albumin, creatinine, uric acid, bilirubin, and electrolytes) and MMP levels. Results Study revealed significant differences between CP patients and the healthy group. CP patients exhibited lower levels of total protein, albumin, magnesium, and phosphorus but higher levels of creatinine, uric acid, chloride, and total bilirubin. Elevated liver enzyme levels, although observed, showed variable statistical significance. However, the serum level of MMP-9 was markedly elevated in CP patients, highlighting its potential role in blood-brain barrier disruption and tissue damage. The MMP-2 level in CP patients was mildly high, which was statistically non-significant. The demographic analysis indicated higher CP prevalence in rural areas, with parental consanguinity being a notable factor. Mixed CP was the most common subtype observed (57%). Conclusion This study highlights the systemic impact of CP on biochemical and extracellular markers, particularly the role of MMP-9 in disease pathology. These findings provide valuable insights into CP’s etiopathogenesis, paving the way for further research and potential therapeutic interventions.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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