인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Objectives Hashimoto’s thyroiditis (HT) is a complex metabolic autoimmune disease. FOXs participate in many cellular metabolic processes and control many related genes. This study aimed to investigate FOXO1, FOXP1 and FOXP2 protein levels in HT disease. Methods The study included 38 patients diagnosed with HT and 38 healthy individuals at the Department of Endocrinology and Metabolic Diseases at Sivas Cumhuriyet University Hospital. Venous blood samples were taken from the individuals in the study groups and serum was obtained. Serum FOXO1, FOXP1 and FOXP2 protein levels were analyzed using the enzyme-linked immunosorbent assay (ELISA) method. Results Serum FOXO1 and FOXP2 protein levels were found to be lower in the HT patient group compared to the control group (p< 0.001 ). FOXP1 concentration was found to be lower in the patient group, but this decrease was not significant (p> 0.05 ). Thyroid stimulating hormone (TSH), anti TPO, antithyroglobulin (anti Tg) and AST levels were found to be higher in HT patients compared to the control group, while T4 levels were found to be lower. According to protein-protein interaction (PPI) analysis, these proteins were found to interact highly with each other and are generally involved in T cell mechanisms. Conclusions HT is a common autoimmune disease and is metabolically associated with many pathways. This cross-sectional study is only a preliminary study on the possible association between HT and FOX family proteins.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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