인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
ABSTRACT Salpingitis is a highly prevalent disease that reduces production performance and egg quality in laying hens, severely impeding the sustainable development of the egg‐laying industry. Fructooligosaccharides (FOS) play a significant role in regulating gut health and immune function. However, the mechanisms by which FOS alleviates salpingitis remain unclear. This study aimed to elucidate how FOS mitigates salpingitis using multi‐omics approaches. A total of 270 34‐week‐old Hy‐Line Brown laying hens were randomly assigned to three groups: a control group with a basal diet (CN), a lipopolysaccharide (LPS)‐challenged group on a basal diet (CN_LPS), and an FOS‐supplemented group (1 g/kg diet) with LPS challenge (FOS_LPS). The results showed that the supplementation of FOS significantly ameliorated LPS‐induced inflammation and atrophy in the magnum of hens ( p < 0.05). The mRNA expression levels of TLR2 , MYD88 , NF‐κB , and COX2 in the FOS_LPS group were significantly reduced in the magnum compared to the CN_LPS group ( p < 0.05). In contrast, the expression of ABCA9 , BIRC5 , and MYRF genes was significantly higher in the FOS_LPS group than in the CN_LPS group. Compared to the CN_LPS group, the FOS_LPS group exhibited a reduction in the abundance of Rikenellaceae _ RC9 _ gut _ group and Alistipes , whereas the abundances of Lactobacillus , Ruminococcus _ torques _ group , and Phascolarctobacterium were increased in cecal chyme. In addition, the FOS_LPS group exhibited elevated relative concentrations of S‐lactoylglutathione and thymol sulfate in plasma as compared to the CN_LPS group. Collectively, FOS mitigated LPS‐induced salpingitis by modulating key inflammatory pathways, restoring gut microbiota (e.g., increased Lactobacillus , decreased Rikenellaceae ), and enhancing metabolic homeostasis.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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