인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
<h2>Abstract</h2><h3>Background</h3> The relationship between timing of adjuvant chemotherapy and survival for early-stage, node-negative small cell lung cancer is not well defined, and no formal guidelines exist. We sought to evaluate whether increasing the time between surgery and adjuvant chemotherapy for pathologic stage I-IIA SCLC would be associated with worse survival. <h3>Methods</h3> The association between timing of adjuvant chemotherapy and survival for patients with pathologic stage I-IIA (pT1-2N0M0) SCLC who have 1 or fewer co-morbidities in the National Cancer Database from 2004-2021 was assessed using multivariable Cox regression analysis with penalized smoothing spline functions and propensity score-matched analysis. Adjuvant chemotherapy received within 21-40 days of surgery was classified as "earlier" while adjuvant chemotherapy received 41-90 days after surgery was classified as "later." <h3>Results</h3> Of 927 patients who met study criteria, the median time to adjuvant chemotherapy was 41 days (interquartile range, 34, 53). In multivariable and propensity score-matched analyses, there was no significant difference in overall survival between earlier and later adjuvant chemotherapy. These findings were consistent when limited to patients who were discharged within 4 days of surgery or when adjusting for minimally invasive surgical approaches. <h3>Conclusions</h3> In this national analysis of patients with early-stage node-negative SCLC, there was no significant difference in overall survival based on the timing of adjuvant chemotherapy.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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