인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Background Glioblastoma is a highly aggressive subtype of glioma. The alteration of non-coding RNA (lncRNA H19 and microRNA-152) in glioblastoma tissues promotes cell proliferation, migration, and invasion, while the exact relationship with glioblastoma is still uncertain with their genes (PTEN, KRAS, and NDRG1). This study aimed to identify new potential biomarkers for early diagnosis and novel therapeutic targets. Methods In a descriptive cross-sectional study, we employed quantitative real-time PCR for expression of lncRNA H19, miRNA-152, and their target genes in 84 glioblastoma specimens compared to 35 control samples (low-grade glioma, astrocytic astrocytoma, normal brain tissues). Additionally, for differential expression profile, predictive significance, and survival analysis, receiver operating characteristic analysis and Kaplan–Meier survival plot were used. Results The expression levels of lncRNA H19 and miR-152 were significantly altered in glioblastoma patients compared to those with low-grade glioma and normal brain tissues. Moreover, KRAS and NDRG1 showed significant upregulation in glioblastoma. It was demonstrated that lncRNA H19 has diagnostic values with AUC > 0.7 that differentiated glioblastoma from non-cancerous lesions and low-grade glioma. Nevertheless, KRAS and NDRG1 with AUC > 0.9 and > 0.8, respectively, distinguished between glioblastoma and all other comparative groups including non-cancerous lesions, low-grade glioma, and astrocytic astrocytoma. Furthermore, poor overall survival was observed with a median survival rate of 15 months. Conclusions The long non-coding RNA H19, along with KRAS and NDRG1, has shown promise as biomarkers for differentiating between glioblastoma, lower-grade glioma, and non-malignant lesions. Key points The expression levels of the lncRNA H19 and miR-152 were significantly altered in Glioblastoma patients compared to those with Low Grade Glioma and normal brain tissues. The lncRNA H19, along with the genes KRAS and NDRG1, have shown promise as biomarkers for differentiating between Glioblastoma, Low Grade Glioma, and normal brain tissues.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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