인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Introduction Multiple-site neural tube defect is a congenital defect at two or more locations along the neural axis. Double-site neural defects are very rare, having a normal segment between two neural tube defects, and are different from complex spinal defects. Various theories have been proposed regarding the occurrence of these defects, including risk factors like folic acid deficiency, environmental factors and genetic factors. Recently, the most accepted theory is based on mechanochemical models, which propose the role of mechanical forces and cellular biomechanics in neural tube closure. The Sonic Hedgehog pathway and its disruption lead to defective neurulation and thus the formation of neural tube defects. Case presentation We received two patients with double-site neural tube defects. One patient was a 5-month-old child with unruptured swellings at the occipital region and lumbar spinal region. The second patient was a 16-day-old child with unruptured swelling in the occipital region and ruptured swelling in the dorsal spinal region. Operative technique In one case, the cranial defect was repaired, and the spinal defect, being small, was kept under observation and follow-up. Hydrocephalus was managed with a ventriculoperitoneal shunt. In the second case, both defects were primarily repaired with a pedicled flap closure for the large spinal defect. Conclusion Multiple-site neural tube defects are a very rare entity caused by defective neurulation during embryogenesis. The management is based on surgeons’ experience in handling cases requiring surgical intervention or observation.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
