인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
It has been recognized that chronic inflammation, which differs in mechanism from acute inflammation triggered by normal immune responses, induces various diseases, including lifestyle-related diseases. Sudachitin (4’,5,7-trihydroxy-3’,6,8-trimethoxyflavone) and demethoxysudachitin (4’,5,7-trihydroxy-6,8-dimethoxyflavone) are types of polymethoxyflavones found in the peel of sudachi ( Citrus sudachi ). This study focused on evaluation of the anti-inflammatory effects of these compounds, their mode of action, and their effect in vivo . Mouse macrophage cell line RAW264.7 cells and primary peritoneal macrophages (P-mac) were cultured with sudachitin or demethoxysudachitin, followed by stimulation with lipopolysaccharide (LPS) to induce an inflammatory response. Sudachitin and demethoxysudachitin suppressed IL-6, TNF-α, nitric oxide (NO) and MCP-1 production by RAW264.7 cells without cytotoxicity. Regarding their mode of action, they downregulated the activation of the MAPK and NF-κB pathways activated by LPS, thereby inhibiting the gene expression of inflammatory factors and suppressing the inflammatory response. Similarly, both compounds suppressed the production of inflammation mediators of in P-mac. Sudachitin exhibited a stronger inhibitory effect than demethoxysudachitin, suggesting that the methoxy group at the 3’ position of sudachitin enhances its anti-inflammatory effect. To examine the anti-inflammatory effects in vivo , mice were orally administered samples for seven days and then subjected to LPS-induced systemic inflammation. Oral administration in the systemic inflammation model mice resulted in reduced blood levels of inflammatory cytokines. These findings confirm the efficacy of sudachitin and demethoxysudachitin in exerting anti-inflammatory effect.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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