인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Antibiotic misuse has triggered a global health crisis due to the rise of antimicrobial-resistant microorganisms. Recent studies suggest that nanoparticles (NPs), particularly silver nanoparticles, may provide a solution. However, their toxicity necessitates the development of novel carriers to enhance targeting while minimizing cytotoxicity. This study aimed to synthesize, characterize mesoporous silica nanoparticles (MSN) incorporated with silver alone or combined with zinc, and evaluate their antibacterial, antibiofilm, and cytotoxic properties. Characterization through X-ray diffraction (XRD) and scanning electron microscopy (SEM), revealed particle sizes between 413 and 560 nm. Antibacterial activity was assessed via the broth-dilution method against Staphylococcus aureus ATCC 25,923, Escherichia coli ATCC 25,922, Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 33,591, and five multidrug-resistant pathogens (MDR). Two types of silver-incorporated mesoporous silica nanoparticles were synthesized: Ag/MCM-48 (10 mmol Ag) and Ag/Zn/MCM-48 (10 mmol Ag + 10 mmol Zn). The minimum inhibitory and minimum bactericidal concentrations ranged from 7.8 to 31.25 and 7.8 to 62.5 µg/mL, respectively. Ag/MCM-48 NPs exhibited 78% antibiofilm activity against MRSA ATCC 33,591, while Ag/Zn/MCM-48 NPs displayed up to 90% antibiofilm activity against MDR bacteria. Cytotoxicity assays revealed promising results, with CC<sub>50</sub> values of 169.16 ± 6.43 µg/mL and 19.95 ± 0.63 µg/mL for Ag/Zn/MCM-48 NPs and Ag/MCM-48 NPs against Vero cell line, respectively. The IC<sub>50</sub> values of Ag/Zn/MCM-48 and Ag/MCM-48 NPs were 62.17 ± 2.15 µg/mL and 3.58 ± 0.12 µg/mL against Caco-2 cell line, respectively. Accordingly, our synthesized silver/zinc incorporated mesoporous silica NPs present a safer antibacterial and antibiofilm agent with lower cytotoxicity than silver NPs, making them a promising alternative for combating MDR bacteria.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
