인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Thyroid hormone resistance (RTH) is a rare genetic disorder characterized by diminished responsiveness of target tissues to thyroid hormones, primarily due to mutations in the thyroid hormone receptor-beta (TR-β) gene. This condition could lead to an increased level of Thyroid stimulating hormone (TSH) and varying degrees of hypothyroid symptoms, despite normal or elevated levels of circulating thyroid hormones. Concurrently, Crohn's disease (CD), an inflammatory bowel disease, poses significant diagnostic and therapeutic challenges due to its multifactorial etiology and association with various autoimmune disorders. This case report describes a 30-year-old female patient diagnosed with both RTH and CD. Given a history of thyroidectomy, the patient was on Levothyroxine supplement and also was taking corticosteroids for Crohn's disease. Despite adherence to therapy, persistently elevated TSH levels were noted, and the patient still exhibited signs of hypothyroidism. Altogether, it raised suspicions for RTH. After 1 year, we successfully managed her Crohn's disease, achieving sustained remission. Surprisingly, clinical and biochemical markers of hypothyroidism also showed significant improvement. This case illustrates the intricate relationship between autoimmune conditions and thyroid dysfunction, emphasizing the necessity for comprehensive evaluation in patients with overlapping symptoms. The findings highlight the importance of recognizing RTH in patients with unexplained thyroid abnormalities, particularly in the context of coexisting inflammatory bowel diseases, to optimize management and improve patient outcomes.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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