인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Nissen fundoplication is an effective surgical treatment for the treatment of gastroesophageal reflux disease but the exact mechanism by which it works remains debatable. We determined the effects of Nissen (360° wrap) and Toupet (270° wrap) fundoplication on the esophagogastric junction (EGJ) pressure in response to distension of the stomach in an ex-vivo preparation of the porcine esophagus and stomach. The duodenal opening was sealed, and stomach cannulated for gas insufflation using a barostat device. The effect of gastric distension on the EGJ was measured, before and after fundoplication, using high-resolution esophageal manometry impedance (HRMZ) catheter as well as with the functional luminal imaging probe (FLIP). Prior to fundoplication, insufflation of the stomach resulted in an immediate leakage of gas through the esophageal orifice with minimal gastric distension. Following fundoplication, the stomach distended like a balloon without leakage of air through the esophagus. The HRMZ recordings show an increase in the EGJ pressure with gastric distension that was 2-3 times higher than the increase in gastric pressure. The FLIP detected a graded decrease in the EGJ distensibility with gastric distension following fundoplication. We propose a novel mechanism by which fundoplication builds a mechanical barrier at the EGJ "sphincter like valve" to strengthen the anti-reflux barrier function.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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