인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic necrotizing vasculitis that primarily affects small- to medium-sized vessels and represents a spectrum of diseases with overlapping clinical and immunopathological features. While anti-proteinase 3 (anti-PR3) and anti-myeloperoxidase (anti-MPO) are the most common ANCA autoantibodies, other ANCA specificities, such as anti-elastase, have been described, but their clinical significance remains uncertain. We report the case of a 38-year-old male presenting with chronic rhinosinusitis, nasal crusting, and epistaxis. Imaging revealed a septal perforation, and histopathological analysis showed necrotizing vasculitis. ANCA serology was positive for perinuclear-ANCA (p-ANCA), with negative anti-PR3 and anti-MPO but positive anti-elastase antibodies. A diagnosis of incomplete AAV with a sinonasal granulomatosis with polyangiitis (GPA) phenotype was established. In order to understand the prevalence of anti-elastase antibodies in AAV, a narrative review was conducted. In six retrospective studies, prevalence varied between 0% and 16.7%, suggesting limited diagnostic utility of anti-elastase in AAV. This case highlights the relevance of histopathological confirmation in AAV, particularly in atypical ANCA profiles. Anti-elastase antibodies may have limited value as a biomarker in AAV, given their low prevalence. Immunosuppressive treatment was effective, reinforcing the importance of early recognition and intervention in AAV.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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