인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Infants born at 22 weeks’ gestation represent one of the most vulnerable populations in neonatal care. Despite increasing survival rates with active resuscitation, variability in outcomes remains significant. This study aimed to identify risk factors associated with in-hospital mortality in actively resuscitated infants born at 22 weeks’ gestation. A retrospective case-control study was conducted at Kagoshima City Hospital between January 2006 and December 2023. Fifty-seven live-born infants at 22 weeks’ gestation who received active resuscitation were included. Clinical characteristics and outcomes were compared between survivors and non-survivors. Univariable and multivariable logistic regression analyses were performed. Firth’s correction and cross-validation were used to address small sample size and model robustness. Of the 57 infants included, 19 (33.3%) died during hospitalization. Necrotizing enterocolitis (NEC, stage ≥ II) and maternal hospitalization ≤ 5 days prior to delivery were independently associated with mortality (adjusted odds ratios: 5.4 and 6.4, respectively). Only non-survivors experienced tension pneumothorax or were born outside of tertiary centers. Bacteremia within 10 days and intraventricular hemorrhage grade III–IV were also associated with mortality in univariable analyses. Model performance after sensitivity analyses yielded an AUC of 0.892 and improved calibration. NEC and short maternal hospitalization are significant independent predictors of mortality in infants born at 22 weeks of gestation. Delivery at tertiary centers and timely maternal transfer may improve survival. Further studies are needed to establish preventive strategies for NEC, sepsis, and respiratory complications in this high-risk group.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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