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Springer Science and Business Media LLC npj Parkinson's Disease 11(1)
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    초록·키워드

    This population-based longitudinal cohort study examines the association between ambient air pollution (PM<sub>2.5</sub> and NO<sub>2</sub>) and Parkinson's disease (PD) using a 28% representative sample of Northern Ireland's population (2009-2016). We matched complete address records to annual average PM<sub>2.5</sub> and NO<sub>2</sub> concentrations at a 1 km grid level and tracked PD onset via first receipt of PD medication. After controlling for confounding factors at individual, household, and neighbourhood levels, we found no association between medium-term PM<sub>2.5</sub> or NO<sub>2</sub> exposure and PD onset in the overall cohort, over-50s, or sex-stratified samples. However, a positive association was observed between PM<sub>2.5</sub> exposure and PD onset in those under 50 in 2011, with weaker evidence for NO<sub>2</sub>. We discuss potential etiological and non-etiological explanations for this age-related difference.

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