인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Stress during adolescence leads to the development of major stress-related diseases. The use of psychoactive substances and most psychiatric disorders have been linked to cigarette smoking during adolescence. Na+/K + ATPase isoforms are related to memory formation, stress activity and psychological disorders. Moreover, nicotine downregulates Na+/K + ATPase α2 isoform in rats’ brains. However, its connection to social stress and nicotine addiction is still unclear. Here we aimed for elucidating the effects of nicotine on behavioral parameters and Na+/K + ATPase mRNA in brains of male Swiss Albino mice exposed to chronic stress during adolescence. Adolescent male mice were exposed to the sensory contact model (SCM) for 12 days. Nicotine doses (0.1 and 1 mg/kg) were administered intraperitoneally daily for 14 days after SCM. Distance traveled in open field (OF), time spent in open arms in elevated plus maze (EPM), percentage spontaneous alteration in Y-maze and immobility time in forced swimming test (FST) were used to assess locomotor activity, anxiety, spatial memory and depression, respectively. In addition, qRT-PCR was conducted to measure the mRNA levels of Na+ /K + ATPase isoforms in the brain striatum. Group comparisons were analyzed using one-way analysis of variance (ANOVA). The significantly increased locomotor activity induced by SCM in the aggressive group was significantly reduced by both nicotine treatments. In EPM test, both aggressive and defeated groups showed a significant state of anxiety-like behavior compared to control group which was significantly reduced by 0.1 mg/kg of nicotine. Aggressive and defeated groups showed significant depressive-like response in FST which was almost abolished in defeated group receiving 0.1 mg/kg treatment; however, 1 mg/kg treatment showed the opposite result in the defeated group. SCM significantly increased Na+/K + ATPase-α2 mRNA levels in aggressive and defeated groups compared to control group. In comparison to the control group that received saline, both nicotine treatments significantly increased the levels of Na+/K + ATPase-α2 mRNA in the other two control groups. This study demonstrates nicotine effects on stress-induced behavioural and molecular alterations in a dose dependent manner. By assessing behavioural outcomes and examining the Na⁺/K⁺ ATPase-α2 expression levels, the study advances understanding of nicotine interactions with chronic stress during adolescence, offering insights into mechanisms underlying nicotine’s behavioral effects. Not applicable.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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