인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Weight loss and energy restriction are potential strategies for reducing cancer risk, particularly if they reduce ectopic body fat and improve insulin resistance. This randomised study compared the effects of intermittent energy restriction [IER] to continuous energy restriction [CER] on hepatic, pancreatic and intramuscular fat, and insulin resistance. Premenopausal women with obesity [n = 28] were randomised to 8 weeks of 25% energy restriction: IER [2 days/week 600 kcal/2511kj and 5 days/week Mediterranean diet] versus CER [7 days/week Mediterranean diet]. Changes in body weight, hepatic, pancreatic and calf intramuscular fat fractions [magnetic resonance spectroscopy] and insulin resistance [HOMA and oral glucose tolerance test], body fat and fat free mass [bioelectrical impedance], resting metabolic rate [RMR, indirect calorimetry] and lipids (total, LDL, HDL cholesterol and tryglycerides) were assessed during the energy restricted and normal eating days of IER compared to CER. 9 IER and 11 CER participants completed the trial. IER and CER had comparable reductions in body weight mean [SD]: IER − 6.7[1.4] kg CER − 6.2[2.9] kg, and reductions in hepatic fat fraction mean [SD]: IER − 74.1[22.0]% CER − 51.4[34.8]%, pancreatic fat fraction mean [SD]: IER − 41.1[35.4]% CER − 30.8[25.4]% and calf intramuscular fat fraction mean [SD]: IER − 8.9[27.4]% CER − 2.3[24.1]%. Fasting measures of insulin resistance [HOMA IR, HOMA-β and fasting insulin] reduced in the CER group and with IER when assessed immediately after the two low energy days but were not maintained during normal eating days. There were no changes in 2-hour glucose in either group. The IER and CER groups had comparable reductions in FFM IER − 1.2[1.4] kg CER − 1.2[1.0] kg and RMR IER − 380[594] kj CER − 594[670] kj. Both groups had reductions in total and HDL cholesterol and triglyceride and maintained LDL. IER and CER have comparable reductions in weight and ectopic fat stores, fat free mass and RMR and lipids. The clinical significance of the failure to maintain beneficial insulin sensitivity across the week with IER is not known and requires further study. ISRCTN 10,803,394 Registration date 12/01/2015.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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