인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Objective This study aimed to elucidate the regulatory role of circadian rhythm–related genes (CRGs) in immune cell function and their potential contribution to vitiligo pathogenesis. Characterizing the crosstalk between CRGs and immune cells may yield novel insights into the immune dysregulation underlying vitiligo development. Methods We integrated expression quantitative trait loci (eQTL) data from the eQTLGen and GTEx projects to analyze 2091 CRGs comprehensively. Summary data–based Mendelian randomization (SMR) and heterogeneity in dependent instruments (HEIDI) analyses were performed to identify key CRGs associated with vitiligo. Colocalization analysis and single‐cell RNA sequencing data were used to assess CRG expression in immune cells of vitiligo patients. Results Nine key CRGs were identified, showing significant associations with vitiligo in both eQTL datasets. USP40 , PEBP , NPM , FBXL1 , and GCLC exhibited negative correlations with vitiligo risk, while RPTO , FAM228B , DPH , and CHST1 were positively correlated. Single‐cell analysis revealed reduced CRG expression in vitiligo patients, particularly in natural killer (NK)/T cells, naive T cells, and monocytes. This CRG downregulation correlated with impaired immune cell functionality, implicating circadian dysregulation in the aberrant immune responses characteristic of vitiligo pathogenesis. Conclusion The results demonstrate that CRGs constitute potential regulatory components in vitiligo pathogenesis through their modulation of immune cell function. The identification of both protective and risk‐associated CRGs, coupled with evidence of circadian–immune crosstalk disruption in affected tissues, establishes a new mechanistic framework for understanding vitiligo etiology. These findings not only advance our knowledge of the circadian–immune axis in autoimmune skin disorders but also highlight CRGs as promising therapeutic targets for precision medicine approaches in vitiligo treatment.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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