인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Injectable hydrogels have gained massive attention in the past decade due to the simple operation, the ability to fill irregularly shaped wounds, and high safety. Herein, we design a PEGylated polypeptide with reactive oxygen species (ROS) responsiveness for injectable hydrogel. In brief, poly(ethylene glycol)-block-poly(2-methylthioethyl L-glutamate) was synthesized by ring opening polymerization of N -carboxylic anhydride with thioether group. The obtained amphiphilic copolymer could self-assemble into micelles, which underwent a sol–gel phase transition at 35°C. Carbon-13 nuclear magnetic resonance, dynamic light scattering, and circular dichroism measurements indicated that the partial dehydration of poly(ethylene glycol), the aggregation of micelles, and the change of β-sheet packing of PMLG 15 as temperature increasing were regarded as the main driving forces of gelation. The formed hydrogel was disrupted by 10 mM H 2 O 2 due to the oxidation of hydrophobic thioether groups into hydrophilic sulfoxides. Furthermore, in vitro experiment showed that the hydrogels consisting of thioether groups exhibited cytoprotective ability against the damage of H 2 O 2 -induced oxidative stress to L929 cells. Finally, the aqueous solution of this copolymer rapidly transformed into gel after being injected into the subcutaneous layer of mice.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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