인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Chronic kidney disease (CKD) is a major global health issue, often underdiagnosed due to its asymptomatic progression. Estimated glomerular filtration rate (eGFR) equations are essential for CKD diagnosis and management, but their performance varies across populations and age groups. This study aimed to compare three validated eGFR equations by assessing their impact on CKD classification and patient reclassification in a Romanian adult population. We retrospectively analyzed 135,630 creatinine results from adult patients admitted to a tertiary care hospital in Romania (2021-2023). eGFR was calculated using CKD-EPI 2009, CKD-EPI 2021, and European Kidney Function Consortium (EKFC) equations. Patients were categorized by age and sex, and classified according to KDIGO GFR stages. Reclassification analysis was focused on two medical decision limits: 60, 30 and 15mL/min/1.73 m². Significant differences in CKD staging were observed across equations. CKD-EPI 2021 consistently led to up-classification of GFR category, with up to 29% of patients over 40 years reclassified into less severe stages. In contrast, EKFC assigned more elderly patients, especially women over 65 years, to stage G3a. Correlation between equations ranged from moderate to strong (τ = 0.59-0.88), with better agreement in older age groups. Reclassification was most frequent around the 60 mL/min/1.73 m² threshold. The choice of eGFR equation substantially impacts CKD classification and may influence clinical decision-making and diagnosis. While EKFC and CKD-EPI 2021 correlate with CKD-EPI 2009, they produce divergent staging patterns. Further validation using measured GFR and outcome data is needed.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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