인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Microorganisms inhabiting extreme environmental conditions receive special attention because they possess different adaptations to adverse conditions. Currently, their biotechnological potential and ability to isolate biologically active metabolites have increased. The increasing mortality due to different diseases has become particularly important as one of the notable challenges in modern healthcare. This highlights the necessity of discovering new producers of natural products (NPs). The aim of this study was to evaluate the genetic and biotechnological potential through the assessment of NP synthesis and genome annotation of the thermophilic strain Streptomyces sp. LPB2020-019-1HS. The thermophilic strain was isolated from the Baikal endemic cold water sponge Lubomirskia baikalensis. Subsequently, Streptomyces sp. LPB2020-019-1HS was cultivated at six temperatures ([Formula: see text]C, [Formula: see text]C, [Formula: see text]C, [Formula: see text]C, [Formula: see text]C, and [Formula: see text]C) in twelve nutrient media with different compositions (nutrient rich and nutrient poor). Using high-performance liquid chromatography and mass spectrometry approaches, the synthesis of compounds by the strain was assessed at [Formula: see text]C, [Formula: see text]C, and [Formula: see text]C. Antimicrobial activity was evaluated at all temperatures (from [Formula: see text] to [Formula: see text]C). We demonstrated the presence of antibiotic activity against Bacillus subtilis for strains cultivated at 28 °C, [Formula: see text]C, and [Formula: see text]C. Additionally, we observed activity against Mycobacterium smegmatis when the strain was cultivated at [Formula: see text]C, [Formula: see text]C, [Formula: see text]C, and [Formula: see text]C. Furthermore, the strain exhibited activity against Escherichia coli, Pseudomonas putida, and Candida glabrata when cultured at [Formula: see text]C. Overall, we found that Streptomyces sp. LPB2020-019-1HS produces a family of NPs related to Nocardamine and hypothesized that freshwater Actinobacteria have mechanisms for chelating iron ions, making them available for plants/sponges or other symbiotic organisms. Therefore, our research findings underscore the importance of studying extremophilic microorganisms from Lake Baikal in the context of developing new pharmaceuticals and biotechnological solutions for contemporary healthcare challenges.
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