인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
ABSTRACT Background and Aim In cases of colonic perforation, closure of the defect is the least invasive treatment; however, no dedicated tool has been developed for this purpose, and many cases require stoma creation. This study investigated whether a bioabsorbable polymer sheet (BAPS) can effectively close colonic perforation and induce colonic regeneration at the defect site. Methods Ten mixed‐breed pigs were used. An artificial colon was created using a BAPS composed of a copolymer reinforced with polyglycolic acid fibers. A circular 2‐cm defect was created on the anterior sigmoid colon wall, and the BAPS was patched over the defect. Blood sampling and body weight assessments were performed at 1, 4, and 8 weeks after transplantation. Furthermore, the transplanted site was excised for macroscopic and histological evaluation at 4 and 8 weeks. Results All pigs survived without complications. White blood cell counts exhibited a transient increase at 1 week but normalized rapidly. Body weight increased consistently. At 4 weeks, the BAPS was no longer observed at the transplanted site, and ulcer formation was noted. Histologically, several immature cells accumulated on the epithelial surface. At 8 weeks, the ulcers had reduced in size, and the site was indistinguishable from the surrounding tissue. Histological examination revealed regenerated mucosa and muscularis mucosae resembling native colonic tissue with partial smooth muscle regeneration. The size of the transplanted site was reduced by approximately 26%. Conclusions The findings suggest that a BAPS can successfully close colonic perforations and regenerate colonic tissue at the defect site.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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