인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Lithium is an effective treatment for mood disorders. However, its mechanism of action concerning its effect on impulsivity and emotional processing is still unclear. The current study aimed to investigate the effect of a 5-day lithium treatment on decision-making, reward-seeking and emotional processing in healthy volunteers. We conducted a double-blind, placebo-controlled, cross-over design study involving sixteen participants aged 18-50 years. Participants received lithium 800 mg once daily followed by matching placebo or vice versa for five days in a random order. Impulsivity and emotional processing were assessed on day six using the Cambridge Gambling Task and the Emotional Testing Battery, respectively. There were significant interactions with large effect sizes between treatment and order for delay aversion (F<sub>1,14</sub> = 13.79, p = 0.002, partial η<sup>2</sup> = 0.496) and reward-seeking (F<sub>1,14</sub> = 34.065, p = < 0.001, partial η<sup>2</sup> = 0.709), but the post-hoc tests suggested only moderate, inconclusive effects at either visit. There was a significant interaction between treatment, emotion and order with a large effect size for the facial expression recognition task. The post-hoc analyses found that during the first visit, relative to placebo, lithium-treated participants showed a higher accuracy in recognising disgust and lower misclassification rates and response bias in recognising sad facial expressions, but higher accuracy and response bias in recognising fear during the second visit. We found a significant interaction between treatment and valence with a large effect size for emotional encoding of self-referent words. Post-hoc analysis showed that lithium was associated with a longer reaction time to encode negative self-referent words than placebo. Short-term lithium treatment in healthy participants produced a positive emotional bias in facial expression recognition and emotional encoding of self-referent words, but no significant effects on impulsivity and reward seeking. The early induction of positive bias in emotional processing may contribute to lithium's effectiveness in mood disorders.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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