인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Growing concerns over the toxicity and environmental impact of traditional nanoparticle synthesis methods have driven the search for safer, more sustainable alternatives. At the same time, the rising prevalence of antibiotic-resistant bacteria and the ongoing challenges in effective cancer treatment emphasize the urgent need for new antimicrobial and anticancer solutions. The manufacture of silver oxide nanoparticles (Ag₂O-NPs) is investigated in this work using Psidium guajava (guava) leaves extract, focusing on their dual biological potential. The use of dangerous chemicals is reduced by this green synthesis technique by employing natural phytochemicals from guava leaves as stabilizing and reducing agents, making it more environmentally friendly compared to traditional chemical approaches. At 435 nm, the biosynthesized Ag₂O-NPs displayed a distinctive surface plasmon resonance (SPR) band. With a polydispersity index (PDI) of 0.368. Nanocrystalline, mostly spherical Ag₂O-NPs with an average size of 25 to 30 nm were successfully formed, according to thorough characterization utilizing FTIR, XRD, SEM, TEM, and EDX. These nanoparticles demonstrated strong antibacterial activity against four clinically relevant, drug-resistant bacterial strains: Pseudomonas aeruginosa ATCC 27853, Salmonella typhimurium ATCC 13311, Escherichia coli ATCC 25922, and Staphylococcus aureus ATCC 29213. Minimum inhibitory concentration (MIC) values ranged from 31.2 to 250 µg/mL, indicating a dose-dependent antibacterial action. Notably, P. aeruginosa and S. aureus showed the highest sensitivity. Cytotoxicity testing further revealed selective anticancer activity, with the Ag₂O-NPs significantly reducing the viability of HepG2 liver cancer cells (IC₅₀ = 73.93 ± 0.49 µg/mL), while displaying lower toxicity toward normal Vero cells (IC₅₀ = 158.1 ± 0.41 µg/mL). These findings suggest that green-synthesized Ag₂O-NPs hold considerable promise as both potent antibacterial agents and effective anticancer therapeutics.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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