인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Background Acute cholangitis is a life-threatening biliary infection associated with substantial morbidity and mortality if not promptly managed. Early identification of high-risk patients is crucial for improved outcomes. The neutrophil–lymphocyte ratio (NLR) is a simple inflammatory marker increasingly recognized as a prognostic tool in infectious diseases. However, data about its utility in predicting morbidity and mortality in Egyptian patients with acute cholangitis remain limited and warrant further investigation. Therefore, this study aimed to evaluate the prognostic value of the neutrophil–lymphocyte ratio in predicting morbidity and mortality in Egyptian patients with acute cholangitis. Methods This cohort study was conducted over six months at Al-Raghy Liver Hospital, Assiut University Hospital, including 100 adult patients diagnosed with acute cholangitis. Clinical and laboratory assessments for all enrolled patients included abdominal ultrasonography, liver function tests, complete blood count for NLR calculation, C-reactive protein, erythrocyte sedimentation rate, and renal function tests. Results The study involved 100 acute cholangitis patients (mean age 51, 60% male), ERCP was the commonest drainage method (60%). The mean NLR was 21.8 ± 11.2. Mortality was 16%; non-survivors had significantly higher NLR (33.4 vs. 19.6, p < 0.001), CRP (173.6 vs. 75.7 mg/L), and more frequent cholangiocarcinoma (87.5%, p < 0.001). ERCP was exclusive to survivors; all non-survivors had PTD ( p < 0.001). Patients with hospital stays ≥ 5 days were older (mean 53.3 vs. 47.2 years), more often male, and had elevated NLR (27.2 vs. 13.9, p < 0.001), WBC $$\:(\times\:{10}^{3}/\mu\:L)$$ , CRP $$\:\left(\text{mg/L}\right)$$ , INR (ratio), and total bilirubin $$\:\left(\text{mg/dL}\right)$$ . An NLR cutoff of 19.5 predicted mortality with 100% sensitivity/NPV, 66.7% specificity, and AUC 0.815; for prolonged stay, sensitivity was 70% and specificity 95%. NLR correlated significantly with age, WBC, INR, CRP, creatinine, and hospital stay, but not with platelets, albumin, or bilirubin. Conclusions This study identified an elevated neutrophil–lymphocyte ratio as a strong predictor of morbidity and mortality in acute cholangitis. Patients with NLR above 19.5 have higher risks of death and prolonged hospital stay. Routine NLR assessment on admission provides a simple, accessible tool for early risk stratification, particularly valuable in low‑resource settings.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
