인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
It has been demonstrated that elevated serum uric acid (sUA) levels elicit both pro-inflammatory and pro-oxidative effects. A growing body of evidence suggests that this may play a contributory role in the development of Non-alcoholic fatty liver disease (NAFLD) in children with obesity. The objective of the present study is to evaluate the association between sUA levels, the sUA/creatinine (Cr) ratio and paediatric NAFLD. This single-center, cross-sectional, comparative study was conducted at a tertiary care center. The study cohort comprised 228 patients with obesity (body mass index (BMI) ≥ 95th percentile) and 167 healthy controls without obesity or overweight. Both groups were 9-18 years of ages, matched for sex and pubertal stage. A diagnosis of NAFLD was made following an ultrasound examination of the liver, with other possible causes of hepatic disease being excluded. A significantly elevated level of sUA, and sUA/Cr values weres observed in the group of patients with obesity in comparison to the control group (p < 0.001). In the group with obesity, NAFLD was detected by abdominal ultrasonography in 169 (74.2%) patients, whereas NAFLD was not detected in 59 (25.8%) patients. The levels of sUA and sUA/Cr were significantly elevated in the obese NAFLD group in comparison to the obese non-NAFLD and control groups (p < 0.001). An elevated WC, ALT, and the ratio of sUA/Cr were associated with an increased risk of NAFLD. A one-unit increase in sUA/Cr was found to be associated with an increased risk of NAFLD (OR = 1.323, 95% CI: 1.001-1.748). The findings of our study indicate that an elevated WC, ALT, and the ratio of sUA/Cr were associated with an increased risk of NAFLD. Nevertheless, no such correlation was identified between sUA and NAFLD.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
최근 본 자료 전체보기
