인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Functional anorectal pain (FAP) is a chronic condition with unclear pathophysiological mechanisms that is often linked to psychological distress. This resting-state functional magnetic resonance imaging (rs-fMRI) study investigated aberrant interhemispheric connections in 30 FAP patients versus 21 matched healthy controls (HC) via seed-based functional connectivity (FC) and voxel-mirrored homotopic connectivity (VMHC). Compared with HC, FAP patients presented enhanced FC between the left middle frontal gyrus (MFG.L) and regions such as the right MFG (MFG.R) and left superior temporal gyrus (STG.L). VMHC analysis revealed increased patterns in the MFG.L and left superior medial frontal gyrus (SFGmed.L) in FAP patients. Moreover, the strength of FC between the MFG.L and MFG.R was negatively correlated with age, indicating that this heightened connection may diminish with age. These findings indicate that FAP involves aberrant interhemispheric hyperconnectivity, which may play crucial roles in pain perception and emotional processing. The age-dependent decline in FC highlights the eroding of neuroplasticity in aging patients. These neural alterations could serve as diagnostic biomarkers and provide targets for therapeutic interventions. Our work positions FAP within a brain-gut axis dysregulation framework and suggests circuit-specific therapeutics to restore neural homeostasis.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.