인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Parkinson's disease (PD) is a debilitating neurodegenerative synucleinopathy, characterized by dopaminergic degeneration, pathological deposition of alpha-synuclein (α-Syn), and neuroinflammation in both motor regions of the midbrain and non-motor areas of the cortex. Despite its motor-centric characterization, visual disturbances such as hallucinations, diplopia, altered contrast sensitivity and retinal abnormalities are well-documented non-motor changes of PD. While this evidence points to neuropathological processes in PD that extend beyond the brain, the neuropathological basis of retinal dysfunction and the role of α-Syn remain poorly investigated. Given the central neuropathological role of α-Syn in the PD brain, we assessed whether the retina is affected in a translational rat model of PD based on the intranigral bilateral infusion of toxic oligomers of human α-Synuclein (H-α-SynOs). Rats were stereotaxically injected with H-α-SynOs or PBS (Vehicle) into the substantia nigra pars compacta (SNpc) and sacrificed 3 months post-infusion. Thereafter, several retinal tissue pathological parameters, along with the expression patterns of selected miRNAs and inflammatory markers, were assessed. The retina of rats infused with H-α-SynOs exhibited high levels of phosphorylated-α-Syn (p-α-Syn), along with a significant decrease of tyrosine hydroxylase (TH) expression, reflecting dopaminergic neuron disfunction. Analysis of PD-associated miRNAs in the retina also revealed heightened levels of miR-384-5p, which inversely correlated with the expression of its predicted molecular target, SIRT1, in rats infused with H-α-SynOs. Consistently, H-α-SynOs infusion induced a widespread activation of retinal astrocytes and microglial markers, associated with a heightened proinflammatory cytokine signaling downstream of TLR4/NFκB. Collectively, our data reveal that H-α-SynOs extend their neuropathological effects to retinal damage, reinforcing our rodent model ability to recapitulate PD pathology in both brain and retina. This study underscores the robustness of this preclinical model and its value as translational system for testing proactive interventions targeting PD-related pathology.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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