인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Background Streptococcus pneumoniae remains a significant cause of morbidity and mortality among children under five years of age, particularly in developing countries. This study assessed the prevalence, serotype distribution, and antimicrobial resistance patterns of S. pneumoniae among pediatric patients at Nnamdi Azikiwe University Teaching Hospital, Nnewi, Southeast Nigeria. A cross-sectional hospital-based study was conducted involving 392 children under five years. Demographic data and vaccination history were collected using structured questionnaires. Clinical specimens, including blood, sputum, and nasopharyngeal exudates, were cultured and tested for S. pneumoniae using standard microbiological techniques. Confirmed isolates underwent capsular serotyping via Quellung reaction targeting PCV13-covered serotypes. Antibiotic susceptibility testing was performed using the disc diffusion method in accordance with Clinical and Laboratory Standards Institute guidelines. Results Out of 392 collected samples, 43 isolates (11% at 95% confident interval) tested positive for S. pneumoniae : blood ( n = 9), sputum ( n = 23), and nasal exudate ( n = 11). We analyzed invasive and non-invasive isolates separately. Nine PCV13 serotypes were identified, with serotype 6 A (23.3%) being the most prevalent; non-PCV13 serotypes accounted for 18.6% (8/43). Antibiotic resistance was highest for ceftriaxone (35%) and amoxicillin-clavulanic acid (33%). Intermediate resistance was observed particularly for erythromycin (44%) and trimethoprim-sulfamethoxazole (35%). The highest susceptibility was noted for oxacillin (72%) and tetracycline (65%). All isolates exhibited resistance to at least one antibiotic. Conclusions Serotype 6 A was found in both vaccinated and unvaccinated children, consistent with the circulation of PCV13-covered and non-PCV13 serotypes. The active circulation of antibiotic-resistant S. pneumoniae strains among the pediatric population points to the need for continuous surveillance and tailored intervention strategies to combat resistance and improve vaccine coverage.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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