인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
The Lamiaceae plants are recognized in folk medicine for their antibacterial and anti-inflammatory properties. This study reports the first MS-based metabolomics analysis, integrating with chemometrics to explore metabolome heterogeneity in Salvia rosmarinus Spenn. (rosemary) and Origanum vulgare L. (oregano), and to pinpoint the key metabolites driving their antibacterial, antioxidant, and anti-inflammatory activities. UPLC–QTOF–MS/MS facilitated the identification of 164 metabolites, including flavonoids and hydroxycinnamic acids, which were reported for the first time in these species. For instance, salvianolic acid D and quercetin coumaroylhexoside were detected in rosemary, while salvianolic acid K, cleroden J, and flavonoids like nepitrin were newly reported in oregano. In biological evaluation, rosemary strongly inhibited methicillin-resistant Staphylococcus aureus and Escherichia coli, exhibited the highest radical scavenging capacity in DPPH assay, and showed superior anti-inflammatory effects through COX-II inhibition and TNF-α and NF-κB suppression. In contrast, oregano displayed the strongest reducing power in FRAP assay. Chemometric analyses revealed that flavonoids, hydroxycinnamic acids, and terpenes were the principal discriminating classes. Partial least squares analysis correlated rosemary’s antibacterial and radical scavenging activity with hydroxycinnamic acids, flavonoids, and terpenes, while its anti-inflammatory effects were linked to flavonoids and diterpenes. In oregano, FRAP reducing power correlated with benzyl derivatives, organic acids, and hydroxycinnamic acids.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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