인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Duchenne muscular dystrophy (DMD) is a rare X-linked neuromuscular disease caused by mutations in the DMD gene, leading to progressive muscle weakness, diminished quality of life and premature death. We aimed to develop an epidemiology model for DMD, providing country-specific prevalence estimates of the total diagnosed population and selected subpopulations. To estimate DMD prevalence, country-specific inputs were derived from population statistics and a literature review of epidemiological data. Diagnosed incidences, considering historic trends, were applied to the number of effective live male births each year from 1950 onwards. Newly diagnosed patients entered the model based on the distribution of the age of diagnosis and patients left the model based on birth cohort-dependent survival. The estimated total number of individuals with DMD was calculated for each calendar year as the sum of patients from previous years who had not left the model owing to death and newly diagnosed patients. To assess validity, estimated DMD prevalence was compared with published prevalence. For the year 2023, the estimated total number of individuals with DMD was 5249 in Brazil, 1003 in Canada, 27 931 in China, 2082 in France, 2071 in Germany, 1361 in Italy, 3110 in Japan, 1169 in Spain and 2055 in the UK. Age group distribution was comparable across countries, with an approximately equal representation of paediatric and adult populations. Projections of total number of patients with DMD for each country from the year 2023 to 2040 showed variable trends. In European countries, 65% of patients with DMD were estimated to be non-ambulatory. The model-estimated prevalence showed good alignment with published prevalence. These findings provide robust prevalence estimates that increase our understanding of the epidemiology of DMD.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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