인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Background Glucose tolerance abnormalities are common in cystic fibrosis (CF). However, there is a paucity of data describing glucose intolerance in children with CF and its impact on health-related quality of life (HRQOL). This study aimed to explore the relationship between abnormal glucose tolerance (AGT) and HRQOL in children with CF as well as the degree of disease severity. Methods This cross-sectional study was conducted on 6–13-year-old children attending CF clinics with their parents. Clinical assessment, oral glucose tolerance test (OGTT), and sputum culture evaluation were performed for all patients. HRQOL was measured using the Cystic Fibrosis Questionnaire-Revised (CFQ-R) (child and parent versions). Disease severity was assessed using the Shwachman-Kulczycki score and lung function. The impact of OGTT results on HRQOL and parameters of disease severity was assessed. Results Fifty patients with CF and their caregivers completed the survey. 24% of children were found to have AGT. 76% had normal glucose tolerance (NGT). Children with AGT had reduced HRQOL, more healthcare utilization, and higher disease severity than those with NGT. Moreover, there were strong relationships between the CFQ-R child-reported social functioning, total score, and glucose intolerance ( P = 0.003,0.002). Additionally, parents’ reported treatment burden and school performance were significantly lower among the AGT group ( P = 0.035, 0.007). Conclusions This study signifies that children with CF with glucose intolerance may have unfavorable QOL, worse clinical status, and lower lung function. Additional research addressing effective strategies for early diagnosis and treatment of AGT in children with CF may improve the HRQOL of this patient population.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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