인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Diabetes mellitus is characterized by persistent hyperglycemia, which leads to complications in wound healing, such as prolonged inflammation, reduced angiogenesis, and impaired cellular proliferation. These complications result in chronic wounds, which are prone to infection and difficult to heal. The chronic nature of diabetic wounds, compounded by increased oxidative stress and accumulation of advanced glycation end-products, requires the development of effective therapeutic strategies to enhance wound healing in patients with diabetes. Therefore, there is an urgent need to explore novel and safer therapeutic approaches for diabetic wound management. This study aimed to evaluate the therapeutic potential of abietic acid, a major component of pine rosin, for enhancing wound healing under high-glucose conditions. Human umbilical vein endothelial cells and streptozotocin-induced diabetic mice were used in this study. The effects of abietic acid on cell viability, angiogenesis, and key signaling pathways (protein kinase B, extracellular signal-regulated kinase, p38, and vascular endothelial growth factor) were assessed in vitro, and wound closure was evaluated in vivo. Abietic acid promoted angiogenesis and activated key signaling pathways in vitro. In vivo, abietic acid significantly accelerated wound closure, with the wound area reduced by 93.3% at day 10 compared with 46.5% in controls. These findings suggest that abietic acid can be a beneficial agent for diabetic wound healing and warrants further investigation. Future studies will aim to optimize dosing, examine inflammatory and oxidative stress markers, and validate efficacy in type 2 diabetes models to strengthen clinical translation. Graphical abstract
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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