인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Objectives Human 8-hydroxy guanine DNA glycosylase (hOGG1) is a DNA repair enzyme associated with hepatocellular carcinoma (HCC). This study aimed to investigate the pooled relationship between hOGG1 rs1052133 polymorphism and HCC susceptibility. Methods Eligible articles were searched from PubMed, EMBASE, China Knowledge Network (CNKI), and WanFang databases. Random or fixed effects models were employed to assess pooled odds ratios (ORs) and 95 % confidence intervals (95 % CIs) of the association. Subgroup analysis based on ethnicity and control source was performed to assess the source of heterogeneity. Results High heterogeneity was discovered in five genetic models. Therefore, the pooled association was discovered under the random-effect model. hOGG1 rs1052133 was significantly related to HCC vulnerability under CG + GG vs. CC (OR=1.38, 95 % CI=1.04–1.83), CG vs. CC (OR=1.44, 95 % CI=1.12–1.84) genetic models. Subgroup analysis based on ethnicity indicated that rs1052133 was linked to elevated HCC risk in the Caucasian subgroup under G vs. C (OR=1.76, 95 % CI=1.22–2.56), CG + GG vs. CC (OR=2.72, 95 % CI=1.48–4.99), GG vs. CC (OR=2.51, 95 % CI=1.10–5.72), CG vs. CC (OR=2.66, 95 % CI=1.19–5.96) genetic models. Notably, the ORs were modest when considering the 95 % CIs. The study was largely free of publication bias. Conclusions The hOGG1 rs1052133 was significantly associated with HCC risk, especially in Caucasians.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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