인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Persistent liver injury leads to liver fibrosis, a pathological condition distinguished by the excessive deposition of extracellular matrix components, especially collagen. This condition is a critical stage leading to cirrhosis and hepatocellular carcinoma, so prevention at the early stage is essential. Moringa oleifera seed oil (MOSEIL) contains bioactive compounds such as oleic acid, kaempferol, and quercetin, which exhibit antioxidant, anti-inflammatory, and antifibrotic activities. This research aimed to investigate MOSEIL's preventive potential against liver fibrosis in mice. Hepatocyte injury was assessed by hematoxylin eosin (HE) staining, while collagen accumulation was evaluated with Picrosirius red staining. The results showed that the fibrosis model group experienced changes in liver architecture, hepatocyte degeneration, and inflammatory cell infiltration. In contrast, the MOSEIL treatment group showed histological structure improvement with reduced cell damage and inflammatory infiltration. Picrosirius red staining demonstrated marked collagen deposition in the fibrosis group, whereas the MOSEIL-treated group exhibited a pronounced reduction in collagen accumulation, especially within the perisinusoidal and periportal regions. In conclusion, MOSEIL has potential as a preventive agent for liver fibrosis through histological improvement and inhibition of collagen deposition, thereby supporting its use as a candidate for natural-based therapy.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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