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Walter de Gruyter GmbH Nanotechnology Reviews 14(1)
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    초록·키워드

    Abstract This research was aimed to prepare sulfur nanoparticles (SNPs) using Allium cepa extract and use them in nanocream. Characterization of the SNPs included measurements of zeta size, zeta potential, UV analyses, ATR-FTIR analyses, and SEM analyses. SNPs were tested for antibacterial and antifungal properties. An excision wound model was used to assess SNP-loaded nanocream activities on wound healing. Particle diameter was 125.21 ± 1.54 nm, and PDI was 0.278 ± 0.02 mV, whereas the zeta potential was −14.16 ± 0.54 mV. ATR-FTIR analysis showed that A. cepa extract, SNPs, and nanocream are compatible with each other and their chemical composition does not change. The SNPs were homogeneous and almost round in shape with a diameter of 125 nm. The incorporation of A. cepa SNPs with antibiotics has been shown to be statistically significant against Staphylococcus aureus , Bacillus subtilis , Escherichia coli , Bordetella , and Candida albicans resistance. The nanocream containing SNPs was homogeneous, had a skin-compatible pH value, viscosity, and spreadability. Nanocream showed increased wound healing properties and was not irritating to the skin. A green synthesis of SNPs is effective in promoting antibacterial, antifungal, and wound healing properties.

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