인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
DBpia AI
AI 에이전트
AI 아이디어
AI 리더
AI 뷰어
Citeasy
크롬 서지관리 다운로드
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract The global incidence of obesity and inflammatory bowel disease (IBD) has been rising during recent decades. We aimed to investigate the prospective association between general and central obesities with IBD in a large‐scale, long‐term follow‐up, population‐based cohort. Participants free of IBD at baseline were enrolled in UK biobank from 2006 to 2010. Multiple baseline general and central obesity indices were assessed (i.e., body mass index [BMI], waist circumference [WC], etc.]. Primary outcome was incident IBD, including ulcerative colitis (UC) and Crohn's disease (CD). Cox proportional hazard model was conducted to investigate the association. Overall, 438,172 participants (aged 56.19 ± 8.10 years; 46.6% male) were included. Based on baseline BMI, 141,464 (32.3%), 187,040 (42.7%), and 107,562 (24.5%) were categorized as normal weight, overweight, and obesity, respectively. During a median of 14.6 years' follow‐up, 2856 incident IBD developed. After multivariable adjustment, individuals with obesity had an 18% higher risk of incident IBD compared to those with normal BMI (hazard ratio [HR] = 1.18, 95% confidence interval [CI]: 1.07–1.30). Similarly, participants in the highest WC quartile had a 28% higher IBD risk compared to the lowest quartile (HR = 1.28, 95% CI: 1.13–1.45). Other central obesity measures showed similar patterns, with 13%–39% higher risk of IBD occurrence in the highest quartile versus the lowest quartile. Similar greater risk of UC and CD was also identified in those with general or central obesity. General and central obesities are both associated with an elevated risk of developing IBD, CD, and UC, emphasizing the critical role of obesity management in preventing IBD.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
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