인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
<h2>Abstract</h2><h3>Background</h3> Cutaneous basal cell and squamous cell carcinomas are primarily treated with surgical excision. UK guidelines designate histopathological margins of R0+≥1mm as "clear", R0+<1mm as "close" and R1 as "involved". Close/involved margins confer "high-risk" status, mandating multi-disciplinary team review for consideration of further intervention. We aimed to elucidate long-term outcomes of BCCs and SCCs with close and/or involved margins at primary excision compared to clear margins. <h3>Methods</h3> 694 BCCs and 296 SCCs, median follow-up 3 and 16 months, respectively, at a UK University Hospital. All lesions excised with predetermined margins and subsequent management guided by MDT. Survival analysis and multiple logistic regression employed to study outcomes by margin status at excision. <h3>Results</h3> In 694 BCCs, 539 (77.7%) were clear at both deep and peripheral margins, 127 (18.3%) had a single close/involved margin, and 28 (4.0%) were close/involved at both margins. Of BCCs with close/involved margin(s), 123/155 (79.3%) had no further intervention. BCCs with a single close/involved margin had no increased risk of local recurrence compared to lesions with clear margins (HR 1.23,95%CI [0.41-3.72]). In 296 SCCs, 208 (70.3%) were clear at both margins, 63 (21.3%) had close margin(s), and 25 (8.4%) had involved margin(s). Of SCCs with close margin(s), 43/88 (48.8%) had no further intervention. Lesions with close margin(s) had no increased risk of local recurrence compared to lesions with clear margins (HR 1.39,95% CI [0.49-3.94]). <h3>Conclusions</h3> BCCs and SCCs with low tumour burden at the margins managed by MDT have long-term recurrence risk similar to lesions with clear margins.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.