인문학
사회과학
자연과학
공학
의약학
농수해양학
예술체육학
복합학
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록·키워드
Abstract Multi-metallic MXenes such as entropy-stabilized (TiVNbMo) 4 C 3 T x exhibit synergistic electronic and redox properties beyond those of monometallic MXenes, yet their antibacterial behavior in aqueous environments remains poorly understood. In particular, how multi-elemental composition influences bactericidal mechanisms has not been elucidated. Here, we investigate how multi-metallic composition governs the antibacterial performance of (TiVNbMo)₄C₃Tₓ MXenes in direct comparison with monometallic Ti 3 C 2 T x and Nb 2 CT x . This work links material structure to ROS generation and membrane disruption, providing a mechanistic basis for MXene design. Concentration-dependent colony-forming unit (CFU) assays against Escherichia coli and Staphylococcus aureus revealed that (TiVNbMo) 4 C 3 T x achieved > 98% bacterial viability loss within 4 h at 100–200 μg/mL. Scanning and transmission electron microscopy showed membrane rupture consistent with a nanoknife effect. Furthermore, oxidative-stress analysis by abiotic assays demonstrated that (TiVNbMo) 4 C 3 T x generates stronger oxidative stress, superoxide (O 2 •⁻), and hydroxyl radicals (•OH) than Ti 3 C 2 T x and Nb 2 CT x . Moreover, monometallic MXenes exhibited measurable antibacterial activity; however, the larger-flake, multi-metallic MXene demonstrated superior killing efficiency, particularly at low concentrations, where ROS generation dominated and the nanoknife-like physical effect served as a secondary contribution. These findings confirm that (TiVNbMo) 4 C 3 T x enhances both ROS-mediated and physical antibacterial activity.
인공지능 문자 인식 모델을 통해 추출된 텍스트로, 일부 오타나 오류가 포함될 수 있으나 지속적으로 개선 중입니다.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.
오류를 발견하셨다면 해당 부분을 드래그한 후 ' 를 통해 신고해주세요.