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Springer Science and Business Media LLC Scientific Reports 16(1)
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    초록·키워드

    The escalating prevalence of diabetes mellitus (DM) emphasizes the critical need for early detection of diabetic retinopathy (DR). This study assesses the performance of the autonomous AI-based diagnostic system IDx-DR in detecting DR and its associated confounders in a real-world clinical setting. This prospective cross-sectional study involved 875 diabetic patients with a mean age of 52 years (range: 8-92). Retinal images were captured by trained assistants. IDx-DR results were compared with mydriatic fundus examination (gold standard) and Ophthalmologists' image analysis. Factors impacting image acquisition or analyzability were examined. Among all patients, 10.5% yielded no image in miosis, and 26.1% were unanalyzable by IDx-DR. Confounders affecting image acquisition were examiner, pupil size, patient age and patients' visual acuity. When good quality images were achieved, IDx-DR performed well, particularly in detection of severe DR (sensitivity 94.4%; specificity 90.5%). IDx-DR results exactly matched Ophthalmologists' mydriatic fundoscopy gradings in 54.2% if images of sufficient quality were obtainable. Undergrading of DR severity by IDx-DR was rare (4.8%). IDx-DR shows promise in detecting DR, especially in resource-limited settings and in detecting severe DR. One remaining challenge is good image acquisition in miotic patients.

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