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논문 기본 정보

저자정보
(덕성여자대학교) (덕성여자대학교)
저널정보
한국식품과학회 Food Science and Biotechnology Food Science and Biotechnology vol 18. no 2
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    초록·키워드

    This study investigated the proapoptotic effect of ethanol extracts obtained from dandelion (Taraxacum officinale) flower on human ovarian cancer SK-OV-3 cells. Cells were treated with dandelion flowers ethanol extract (DFE) ranging from 1.5625 to 100 ㎍/㎖ for 24 hr. Significant antiproliferative effects of DFE were first observed from at 6.25 ㎍/㎖ (p<0.05), and this inhibition showed in a dose-dependent manner. When cells were treated with more than 6.25 ㎍/㎖ DFE, cell-cycle analysis showed that DFE caused an increase in the percentage of sub-G0/G1 cells and arrested at the S and G2/M phase in a dose-dependent manner. Moreover, apoptosis induction by DFE involved p53 activation and bax upregulation as well as downregulation of bcl-2. Our findings indicate that DFE resulted in apoptotic cell death, suggesting that DFE possesses potential anticancer properties.

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      UCI(KEPA) : I410-ECN-0101-2013-573-000856252