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논문 기본 정보

자료유형
학술저널
저자정보
(Korea Maritime University) (Korea Maritime University) (Dong-Eui University) (Pukyong National University) (Pukyong National University) (Inje University) (Pukyong National University) (Korea Maritime University)
저널정보
한국식품과학회 Food Science and Biotechnology Food Science and Biotechnology vol 17. no 5
발행연도
수록면
983 - 989 (7page)

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초록· 키워드

Two flavonoids, isorhamnetin 3-O-β-D-glucopyranoside (1) and quercetin 3-O-β-D-glucopyranoside (2), from slander glasswort (Salicornia herbacea, Korean name hamcho) were isolated. Antioxidative and matrix metalloproteinase-9 (MMP-9) inhibitory effects of these compounds were investigated in HT 1080 cell lines. These compounds suppressed the electron spin resonance (ESR) signal intensity on generation of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical in a free-cellular system. Their scavenging effects on generation of intercellular reactive oxygen species (ROS) also exhibited similar trends with DPPH radical in the free cellular system. Also, a control group combined only with Fe(II)-H<sub>2</sub>O<sub>2</sub> resulted in DNA apoptosis by oxidative stress, whereas treatments with these compounds suppressed radical-mediated DNA damage. Intracellular glutathione (GSH) levels were slightly increased in the presence of compound 1 and 2. Moreover, these compounds led to the reduction of the expression levels of MMP-9 without cytotoxic influence. These results suggest that these compounds have a potential as a valuable natural antioxidant and MMP inhibitor related to oxidative stress. Therefore, these compounds not only can be developed as a candidate for a therapeutic potential but also a source for use as ingredients of health foods or functional foods to prevent metastasis involving MMP-9, closely related to ROS.
#Salicornia herbacea #isorhamnetin and quercetin 3-O-β-D-glucopyranosides #reactive oxygen species (ROS) #DNA damage #matrix metalloproteinase-9 (MMP-9)
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목차

  1. Abstract
  2. Introduction
  3. Materials and Methods
  4. Results and Discussion
  5. Acknowledgments
  6. References

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UCI(KEPA) : I410-ECN-0101-2013-573-001007644